Optimization and characterization of lambda-cyhalothrin solid nanodispersion by self-dispersing method.

Pesticide is an important agricultural necessity to control plant diseases and pests, ensuring safe production of food. However, the low efficacy, large dosage and high-frequency use of conventional pesticide formulation seriously induced food safety and ecological environment issues. In this research, lambda-cyhalothrin solid nanodispersion (LCSND) was developed by a self-dispersing method. The mean particle size of the lambda-cyhalothrin solid nanodispersion was 32.7 ± 1.1 nm. It exhibited excellent dispersibility, wettability and stability, especially the improved bioavailability compared to the commercial formulations. Notably, the solid nanodisperison had a small particle size and large specific surface area. The solid nanodispersion without organic solvents can minimize the environment pollution and overcome the instability characteristic of the liquid formulations. Therefore, lambda-cyhalothrin solid nanodispersion has broad application prospects in agricultural production and environmental protection. © 2018 Society of Chemical Industry.