- Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones.
Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones.
Bioorganic & medicinal chemistry letters (2005-04-20)
Paola Barraja, Laura Sciabica, Patrizia Diana, Antonino Lauria, Alessandra Montalbano, Anna Maria Almerico, Gaetano Dattolo, Girolamo Cirrincione, Silvia Disarò, Giuseppe Basso, Giampietro Viola, Francesco Dall'Acqua
PMID15837311
摘要
A series of derivatives of the new ring system thiopyrano[2,3-e]indol-2-one was prepared with the aim of obtaining new photochemotherapeutic drugs. Biological screenings were performed on this new class of photoactivable drugs and a strong antiproliferative effect was observed upon irradiation with UVA light. The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range.