Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2.

Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 2.

Neuroscience letters (2020-11-11)

Katarzyna Stachowicz, Magdalena Sowa-Kućma, Patrycja Pańczyszyn-Trzewik, Paulina Misztak, Marcin Marciniak, Bartosz Bobula, Krzysztof Tokarski

PMID33171212

摘要

Our earlier study demonstrated, that antidepressant-like and also cognitive action of MTEP, a metabotropic glutamate receptor subtype 5 (mGluR5) antagonist, was influenced by cyclooxygenase-2 (COX-2) inhibition in mice. We detected a decrease in the mGluR7 protein level in the hippocampus (HC) of mice co-treated chronically with MTEP and NS398 (a COX-2 inhibitor). We found both antidepressant-like effects and cognitive to be associated with mGlu7 receptor-mediated mechanisms.