- Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae.
Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy (2007-05-29)
Ying-Tsong Chen, Tsai-Ling Lauderdale, Tsai-Lien Liao, Yih-Ru Shiau, Hung-Yu Shu, Keh-Ming Wu, Jing-Jou Yan, Ih-Jen Su, Shih-Feng Tsai
PMID17526756
摘要
A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum beta-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses.