MRI predictors of intracranial hemorrhage in acute ischemic stroke after endovascular thrombectomy therapy.

To investigate the predictors for the occurrence of intracranial hemorrhage (ICH) after endovascular thrombectomy (EVT) therapy in acute ischemic stroke (AIS) patients. Patients with AIS who underwent EVT and bridging therapy were enrolled retrospectively. ICH was evaluated on follow-up noncontrast CT or MRI. Diffusion weighted imaging (DWI) volume, perfusion weighted imaging (PWI) volume, DWI-PWI mismatch (DPM) volume and other clinical data were collected for 135 AIS patients. Multivariate logistic regression analysis was used to predict ICH after therapy in AIS patients. The DWI volume in patients undergoing EVT with ICH was significantly larger than that in patients without ICH (50.61±47.43 vs 26.65±29.51; t=-2.416, P=0.020). For patients treated with bridging therapy, patients with ICH had larger DWI volume (26.32±29.66 vs 13.04±20.14; t=-2.013, P=0.037) and PWI volume (174.21±75.12 vs 129.87±60.29; t=-2.618, P=0.011) than patients without ICH. More patients with ICH were attempted for >3 passes with retriever during EVT than patients without ICH (EVT: 51.72% vs 26.19%; χ2 =5.131, P=0.028; bridging therapy: 48.15% vs 21.62%; χ2 =4.982, P=0.033). Multivariable logistic regression analysis demonstrated that DWI volume (OR, 1.017 (95% CI, 1.002-1.033); P=0.022) and >3 passes with the retriever (OR, 0.327 (95% CI, 0.114-0.936); P=0.037) were independently associated with ICH after EVT in AIS patients. DWI volume (OR, 1.024 (95% CI, 1.011-1.048); P=0.046), PWI volume (OR, 1.010 (95% CI, 1.002-1.018); P=0.016) and >3 passes with the retriever (OR, 0.281 (95% CI, 0.089-0.887); P=0.030) were independently associated with ICH after bridging therapy in AIS patients. DWI volume, PWI volume and >3 passes with the retriever were able to predict the ICH in patients with AIS after EVT therapy.