- Cyclocarioside O-Q, three novel seco-dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus.
Cyclocarioside O-Q, three novel seco-dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus.
Natural product research (2019-06-15)
Tong-Yao Xuan, Jie Tan, Hui-Hui Sun, Can Yang, Wen-Yan Lv, Ji-Hua Zhang, Ke-Qing Zhang, Ze-Qun Nie, Zi-Jun Ye, Xiao-Ai He, Gang-Zhi Zhu, Kang-Ping Xu
PMID31198051
摘要
Three previously undescribed seco-dammarane triterpenoid glycosides O-Q (1-3) along with two known compounds (4 and 5) were isolated and characterized from the leaves of Cyclocarya paliurus. Their structures were determined by comprehensive analysis of 1 D, 2 D NMR and HRESIMS data. Compounds 1-5 were evaluated for their inhibitory effects against human pancreatic tumor (ASPC-1), human gastric carcinoma (SNU5), liver hepatocellular carcinoma (HEPG-2) and human colon tumor (HCT116) cell lines. Among them cyclocarioside P (2) showed somewhat inhibitory activity towards those tumor cells.
材料