Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana.

Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana.

Journal of natural products (2011-02-10)

Uraiwan Songsiang, Tula Thongthoom, Chantana Boonyarat, Chavi Yenjai

摘要

Four new carbazole alkaloids, claurailas A-D (1-4), as well as 12 known carbazoles and three known coumarins were isolated from the roots of Clausena harmandiana. Heptaphylline (6) and 7-methoxyheptaphylline (7) showed strong cytotoxicity against NCI-H187 and KB cell lines with IC(50) values ranging from 1.3 to 2.7 μM. Compound 7 showed no cytotoxicity against Vero cells.