Naphthoquinone-like polyketide isolated from Streptomyces sp. RI-77 and its predicted biosynthetic pathway.

Naphthoquinone-like polyketide isolated from Streptomyces sp. RI-77 and its predicted biosynthetic pathway.

Journal of natural products (2011-12-08)

Miho Izumikawa, Ryutaro Satou, Keiichiro Motohashi, Aya Nagai, Yasuo Ohnishi, Motoki Takagi, Kazuo Shin-ya

摘要

A novel naphthoquinone-like polyketide, JBIR-85 (1), with a unique skeleton and antioxidative activity was isolated from a culture of Streptomyces sp. RI-77. The planar structure of 1 was established on the basis of extensive NMR and MS analyses. The structure of 1 including the absolute configuration was established via X-ray crystallographic analysis. Since 1 exhibits a unique skeleton, we performed feeding experiments to reconfirm the structure and predict the biosynthetic pathway.

材料

产品编号

品牌

产品描述

T3634

Sigma-Aldrich

(+)-α-生育酚, from vegetable oil, Type V, ~1000 IU/g

T1539

Sigma-Aldrich

(+)-α-生育酚, Type VI, from vegetable oil, liquid (≥0.88M based on potency, density and molecular wt.), BioReagent, suitable for insect cell culture, ≥1000 IU/g