- Potentiation of hemostimulating effects of erythropoietin with pegylated hyaluronate-endo-β-N-acetylhexosaminidase.
Potentiation of hemostimulating effects of erythropoietin with pegylated hyaluronate-endo-β-N-acetylhexosaminidase.
Bulletin of experimental biology and medicine (2012-11-01)
A M Dygai, G N Zyuz'kov, V V Zhdanov, E V Udut, R V Gurto, L A Miroshnichenko, E V Simanina, T Iu Khrichkova, L A Stavrova, A V Chaikovsky, A V Artamonov, A A Bekarev, P G Madonov, M Iu Minakova, T S Markova
PMID23113258
摘要
Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensification of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-inducing environment cells and elevation of serum erythropoietin concentration. The use of the enzyme allows 10-fold reduction of the maximum effective erythropoietin dose.