- Effect of hyaluronate-endo-β-N-acetylhexosaminidase pegylated by electron beam synthesis nanotechnology on the formation of hematological shifts in chronic hepatitis.
Effect of hyaluronate-endo-β-N-acetylhexosaminidase pegylated by electron beam synthesis nanotechnology on the formation of hematological shifts in chronic hepatitis.
Bulletin of experimental biology and medicine (2013-01-19)
A M Dygai, G N Zyuz'kov, R V Gurto, V V Zhdanov, E V Udut, L A Miroshnichenko, E V Simanina, L A Stavrova, A V Chaikovskii, T S Markova, M Yu Minakova, A V Artamonov, A A Bekarev, P G Madonov, D N Kinsht
PMID23330143
摘要
We studied the effect of mobilization of bone marrow multipotent stem cells induced by intragastric administration of pegylated hyaluronate-endo-β-N-acetylhexosaminidase (Peg-HEAHA) on hemopoiesis under conditions of experimental chronic hepatitis. Peg-HEAHA increased the counts of hemopoietic precursors in the hemopoietic tissue against the background of their decelerated maturation. This was paralleled by a short-term decrease in the count of neutrophilic granulocyte in the bone marrow and a slight increase of neutrophil count in the peripheral blood.