CN
- Rapid RNA cleavage using an antisense system with two terpyridine.Cu(II) complexes.
Rapid RNA cleavage using an antisense system with two terpyridine.Cu(II) complexes.
Nucleosides, nucleotides & nucleic acids (2001-09-21)
H Inoue, T Furukawa, T Tamura, A Kamada, E Ohtsuka
PMID11563126
摘要
An effective approach to promote sequence-specific RNA cleavage by an antisense 2'-O-methyloligonucleotide with a terpyridine.Cu(II) complex attached at the 5'-end was developed. We have synthesized a Cu(II) complex 3'-conjugate, which when used in a tandem fashion, greatly enhanced the RNA cleavage efficiency.
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