Photoreactivity of 5-iodouracil-containing DNA-Z alpha complex.

It is revealed that double-strand RNA adenosine deaminase 1 binds to Z-DNA and NH2-terminus Z alpha domain is responsible for the high affinity binding. In order to investigate the structure of Z-DNA induced by Z alpha, the photoreactions of 5-halouracil-containing Z-DNA in the presence and the absence of Z alpha were investigated. It was demonstrated that the C2' alpha-hydroxylated product was efficiently produced in Z-DNA induced by Z alpha compared to that under high salt concentration.