- Tri- and hexavalent mannoside clusters as potential inhibitors of type 1 fimbriated bacteria using pentaerythritol and triazole linkages.
Tri- and hexavalent mannoside clusters as potential inhibitors of type 1 fimbriated bacteria using pentaerythritol and triazole linkages.
Chemical communications (Cambridge, England) (2007-01-16)
Mohamed Touaibia, Tze Chieh Shiao, Alex Papadopoulos, Jonathan Vaucher, Qingan Wang, Karima Benhamioud, René Roy
PMID17220977
摘要
Several oligomannoside clusters having a hundred-fold increase in affinities toward E. coli were synthesized by Cu(I)-catalyzed [1,3]-dipolar cycloadditions using pentaerythritol scaffolds bearing either alkyne or azide functionalities.