- An improved synthesis of (+/-)-N'-nitrosonornicotine 5'-acetate.
An improved synthesis of (+/-)-N'-nitrosonornicotine 5'-acetate.
The Journal of organic chemistry (2009-03-11)
Gwendolyn A Marriner, Sean M Kerwin
PMID19271724
摘要
A concise and efficient route to (+/-)-N'-nitrosonornicotine 5'-acetate (NNN-5'-OAc), a stable precursor of the active metabolite 5'-hydroxy(+/-)-N'-nitrosonornicotine NNN-5'-OH is reported. The synthesis utilizes sulfinimine chemistry to give (+/-)-NNN-5'-OAc in 26% yield over 4 steps.
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Supelco
(±)-N′-亚硝基降烟碱 (NNN) 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®