Asymmetric Rh-catalyzed intermolecular hydroacylation of 1,5-hexadiene with salicylaldehyde.

Asymmetric Rh-catalyzed intermolecular hydroacylation of 1,5-hexadiene with salicylaldehyde.

Chemical & pharmaceutical bulletin (2009-10-06)

Yasuhiro Inui, Masakazu Tanaka, Masanori Imai, Keitaro Tanaka, Hiroshi Suemune

PMID19801881

摘要

Asymmetric intermolecular hydroacylation between salicylaldehyde (1) and 1,5-hexadiene (2) using a combination of [RhCl(C(8)H(14))(2)](2) (0.10 eq), (S)-BINAP (0.10 eq), and ZnBr(2) (0.20 eq) afforded an enantiomerically enriched hydroacylated product iso-3 of 84% ee, along with an achiral product normal-3.

材料

货号

品牌

产品描述

230022

Sigma-Aldrich

溴化锌, 99.999% trace metals basis

451398

Sigma-Aldrich

溴化锌, AnhydroBeads^™, −10 mesh, 99.999% trace metals basis