The chemical structure of prostaglandin X (prostacyclin).

The chemical structure of prostaglandin X (prostacyclin).

Prostaglandins (1976-12-01)

N Whittaker, S Bunting, J Salmon, S Moncada, J R Vane, R A Johnson, D R Morton, J H Kinner, R R Gorman, J C McGuire, F F Sun

PMID12538

摘要

The chemical structure of prostaglandin X, the anti-aggregatory substance derived from prostaglandin endoperoxides, is 9-deoxy-6, 6alpha-epoxy-delta5-PGF1alpha. The stable compound formed when prostaglandin X undergoes a chemical transformation in biological systems in 6-keto-PGF1alpha. Prostaglandin X is stabilized in aqueous preparations by raising the pH to 8.5 or higher. The trivial name prostacyclin is proposed for 9-deoxy-6, 9alpha-epoxy-delta5-PGF1alpha.