- Creation of an artificial metalloprotein with a Hoveyda-Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin.
Creation of an artificial metalloprotein with a Hoveyda-Grubbs catalyst moiety through the intrinsic inhibition mechanism of α-chymotrypsin.
Chemical communications (Cambridge, England) (2012-01-04)
Takashi Matsuo, Chie Imai, Takefumi Yoshida, Takashi Saito, Takashi Hayashi, Shun Hirota
PMID22212522
摘要
An L-phenylalanyl chloromethylketone-based inhibitor equipped with a Hoveyda-Grubbs catalyst moiety was regioselectively incorporated into the cleft of α-chymotrypsin through the intrinsic inhibition mechanism of the protein to construct an artificial organometallic protein.
材料