Merck
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  • Low-dose propofol for the abortive treatment of pediatric migraine in the emergency department.

Low-dose propofol for the abortive treatment of pediatric migraine in the emergency department.

Pediatric emergency care (2012-11-29)
David C Sheridan, David M Spiro, Thuan Nguyen, Thomas K Koch, Garth D Meckler
摘要

Limited progress has been made in the past decade for abortive treatment of migraine headache in the pediatric emergency department (PED). Propofol, a general anesthetic, has been reported to be effective in the treatment of refractory headaches in adults at subanesthetic doses but never in the pediatric population. The goal of this study was to review our institution's experience with subanesthetic doses of propofol for the abortive treatment of pediatric migraine and compare propofol with standard abortive therapy in the PED. Retrospective review of all patients discharged from the Oregon Health and Science University PED with a diagnosis of migraine headache from January 2010 to July 2011. Patients treated with subanesthetic doses of propofol were compared with matched controls who received standard abortive migraine therapy, defined as the combined use of a nonsteroidal anti-inflammatory medication, diphenhydramine, and prochlorperazine. Outcome variables of interest included reduction of pain as measured on a self-reported visual analog scale and length of stay after administration of initial abortive medication. Patients who received subanesthetic doses of propofol achieved significantly greater reduction in pain scores (80.1% vs 61.1%; P < 0.05) compared with matched controls as well as shorter stay (122 minutes vs 203 minutes; P = 0.2) after treatment. No adverse effects (hypotension, respiratory depression, or hypoxia) were recorded in either group. Propofol seems to be effective for the abortive treatment of pediatric migraine headache in the PED. Further prospective trials are warranted to either support or refute these initial findings.

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Supelco
苯海拉明 盐酸盐, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
苯海拉明 盐酸盐, ≥98% (HPLC)
Supelco
盐酸苯海拉明标准液 盐酸盐, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
苯海拉明 盐酸盐, European Pharmacopoeia (EP) Reference Standard