PHR1015
苯海拉明 盐酸盐
Pharmaceutical Secondary Standard; Certified Reference Material
别名:
2-二苯基甲氧基- N , N -二甲基乙胺 盐酸盐, N -（2-二苯基甲氧基乙基）- N , N -二甲胺 盐酸盐
等级
certified reference material
pharmaceutical secondary standard
质量水平
Agency
USP 1218005
traceable to Ph. Eur. D2000000
API类
diphenhydramine
CofA
current certificate can be downloaded
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
pharmaceutical (small molecule)
包装形式
neat
储存温度
2-30°C
SMILES字符串
Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2
InChI
1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H
InChI key
PCHPORCSPXIHLZ-UHFFFAOYSA-N
基因信息
human ... HRH1(3269)
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相关类别
一般描述
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
应用
Diphenhydramine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
分析说明
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
其他说明
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7790 in the slot below. This is an example certificate only and may not be the lot that you receive.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Quantitative analysis of liquid formulations using FT-Raman spectroscopy and HPLC: The case of diphenhydramine hydrochloride in [TM="Benadryl"]
Orkoula MG, et al.
Journal of Pharmaceutical and Biomedical Analysis, 41(4), 1406-1411 (2006)
Optimization and validation of a method for the determination of caffeine, 8-chlorotheophylline and diphenhydramine by isocratic high-performance liquid chromatography: Stress test for stability evaluation
Barbas C, et al.
Journal of Chromatography A, 870(1), 97-103 (2000)
Development and validation of a capillary electrophoresis method for the determination of codeine, diphenhydramine, ephedrine and noscapine in pharmaceuticals
Gomez MR, et al.
Il Farmaco (Societa Chimica Italiana : 1989), 60(1), 85-90 (2005)
Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography
Martinez-Algaba C, et al.
Journal of Pharmaceutical and Biomedical Analysis, 40(2), 312-321 (2006)
Manoj Reddy Medapati et al.
International journal of molecular sciences, 22(18) (2021-09-29)
Bitter-taste receptors (T2Rs) have emerged as key players in host-pathogen interactions and important modulators of oral innate immunity. Previously, we reported that T2R14 is expressed in gingival epithelial cells (GECs) and interacts with competence stimulating peptides (CSPs) secreted by the
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