- One-pot efficient synthesis of N(α)-urethane-protected β- and γ-amino acids.
One-pot efficient synthesis of N(α)-urethane-protected β- and γ-amino acids.
Amino acids (2012-12-20)
Marta Cal, Mariusz Jaremko, Łukasz Jaremko, Piotr Stefanowicz
PMID23250684
摘要
1-[(4-Methylphenyl)oxy]pyrrolidine-2,5-dione and 1-[(4-methylphenyl)oxy]piperidine-2,6-dione react in a Lossen-type reaction with primary alcohols in the presence of triethylamine to furnish corresponding N(α)-urethane-protected β-alanine and γ-aminopropionic acid (GABA), respectively, with excellent yields and purities, in an essentially "one-pot" procedure.