- Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents.
Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents.
Bioorganic & medicinal chemistry letters (2012-12-26)
Jian-Li Shang, Hui Guo, Zai-Shun Li, Biao Ren, Zheng-Ming Li, Huan-qin Dai, Li-Xin Zhang, Jian-Guo Wang
PMID23265879
摘要
A total of 29 novel sulfenamide compounds were synthesized, spectroscopically characterized and evaluated in vitro for antimicrobial activity against various infectious pathogens. Compounds 1b and 2c exhibited potent inhibition against clinical Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentration (MIC) values of 1.56 μg/mL.