[Antioxidant and cerebroprotective action of N-,S-chinazolone derivative under rat brain ischemia].

[Antioxidant and cerebroprotective action of N-,S-chinazolone derivative under rat brain ischemia].

Ukrains'kyi biokhimichnyi zhurnal (1999 ) (2013-01-25)

Iu I Hubs'kyĭ, I F Bielenichev, S I Kovalenko, H H Goriushko, N V Bukhtiiarova, N V Litvinova, V S Nikitin, S V Pavlov, L P Babenko

PMID23342639

摘要

Under modelling of brain ischemia in rats the antioxidant and cerebroprotective action of new N-,S-chinazolone derivative--compound NC-224 has been established. The compensation of pathobiochemical abnormalities in the system "LPO-antioxidant protection" is observed, indicators of carbohydrate metabolism and energy-supply, and morpho-functional status of brain cells are improved under administration of the compound NC-224. Administration of the compound NC-224 to rats promoted a decrease of the lethality index and signs of neurological deficiency.