- A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies.
A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies.
Lab on a chip (2013-02-16)
Lucía D Garza-García, Leydi M Carrillo-Cocom, Diana Araiz-Hernández, Pedro Soto-Vázquez, Julián López-Meza, Eduardo J Tapia-Mejía, Sergio Camacho-León, Erika García-López, Ciro A Rodríguez-González, Mario M Alvarez
PMID23412111
摘要
We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA "zigzag" channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.
材料
Product Number
品牌
产品描述
Supelco
聚甲基丙烯酸甲酯, analytical standard, suitable for gel permeation chromatography (GPC), 100,000
Supelco
聚甲基丙烯酸甲酯, analytical standard, suitable for gel permeation chromatography (GPC), average Mw 97,000 (Typical), average Mn 46,000 (Typical)