Monobenzone, Superfade, vitiligo and confetti-like depigmentation.

Three cases of cutaneous depigmentation after the application of Superfade are presented. Almost total depigmentation occurred on the dorsum of the hands with spread of confetti-like depigmentation to the arms. More distant spread occurred in two cases. Superfade contains 1.5% monobenzyl ether of hydroquinone (monobenzone). This is proposed as the cause of the depigmentation.