- Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors.
Facile one-pot synthesis of thio and selenourea derivatives: a new class of potent urease inhibitors.
Bioorganic & medicinal chemistry letters (2007-09-25)
Kirubakaran Sivapriya, Perumal Suguna, Arun Banerjee, Vadivelu Saravanan, Desirazu N Rao, Srinivasan Chandrasekaran
PMID17889535
摘要
A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate 1 and tetraselenotungstate 2 as sulfur and selenium transfer reagents, respectively, is reported. The compounds were tested for their activity as urease inhibitors and some of the compounds showed potent activity in the nanomolar range towards jack bean urease.
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