Enantioselective Synthesis of L-CCG-I.

Enantioselective Synthesis of L-CCG-I.

The Journal of organic chemistry (2003-08-16)

Subhash P Chavan, Pallavi Sharma, Rasapalli Sivappa, Mohan M Bhadbhade, Rajesh G Gonnade, Uttam R Kalkote

PMID12919057

摘要

Introduction of natural menthol as the chiral auxiliary in a gamma-Br-alpha,beta-unsaturated ester leads to enantioselective generation of three chiral centers in a single step on reaction with a glycine anion equivalent to provide L-CCG-I in 94% ee.