- The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.
The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.
Bioorganic & medicinal chemistry letters (2006-05-03)
Sergio A Alonso De Diego, Marta Gutiérrez-Rodríguez, M Jesús Pérez de Vega, Rosario González-Muñiz, Rosario Herranz, Mercedes Martín-Martínez, Edurne Cenarruzabeitia, Diana Frechilla, Joaquín Del Río, M Luisa Jimeno, M Teresa García-López
PMID16650992
摘要
The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors.
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