Protective effects of a novel thromboxane analog in lethal traumatic shock.

Protective effects of a novel thromboxane analog in lethal traumatic shock.

Prostaglandins and medicine (1979-09-01)

A M Lefer, H Araki, J B Smith, K C Nicolaou, R L Magolda

摘要

Pinane thromboxane A2 (PTA2) an analog of thromboxane A2 that inhibits the formation of thromboxanes as well as antagonizes their biological actions, at an infusion rate of 1.0 mumole . kg-1 . h-1, prolonged survival in traumatic shock in rats. PTA2 also prevented the accumulation of thromboxane B2, the lysosomal protease, cathepsin D, and the cardiotoxic peptide MDF in the circulating blood.