Tylophora compounds as Na+/K(+)-ATPase inhibitors.

Tylophora compounds as Na+/K(+)-ATPase inhibitors.

General pharmacology (1993-09-01)

J N Gnabre, J L Pinnas, R B Bates, D P Dolata, S Gangwar

摘要

1. Acetyltylophoroside (AcT) and tylogenin inhibit Na+/K(+)-ATPase in spite of having structures very different from cardiac glycosides (CGs). 2. Calculation of the lowest energy conformations of AcT and tylogenin and superpositions of these with the X-ray conformations of CGs and chlormadinone acetate led to a model for the interaction of these different types of Na+/K(+)-ATPase inhibitors with the receptor.