Synthesis of Dolastatin 15 mimetic peptoids.

Synthesis of Dolastatin 15 mimetic peptoids.

Bioorganic & medicinal chemistry letters (1999-01-01)

J Schmitt, M Bernd, B Kutscher, H Kessler

摘要

Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human cancer cell lines and did not show any cytostatic properties.