Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.

Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.

Nature genetics (2011-02-01)

Sara Lindström, Celine M Vachon, Jingmei Li, Jajini Varghese, Deborah Thompson, Ruth Warren, Judith Brown, Jean Leyland, Tina Audley, Nicholas J Wareham, Ruth J F Loos, Andrew D Paterson, Johanna Rommens, Darryl Waggott, Lisa J Martin, Christopher G Scott, V Shane Pankratz, Susan E Hankinson, Aditi Hazra, David J Hunter, John L Hopper, Melissa C Southey, Stephen J Chanock, Isabel dos Santos Silva, JianJun Liu, Louise Eriksson, Fergus J Couch, Jennifer Stone, Carmel Apicella, Kamila Czene, Peter Kraft, Per Hall, Douglas F Easton, Norman F Boyd, Rulla M Tamimi

PMID21278746

摘要

High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.