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Merck
CN
  • Early intravenous ibuprofen decreases narcotic requirement and length of stay after traumatic rib fracture.

Early intravenous ibuprofen decreases narcotic requirement and length of stay after traumatic rib fracture.

The American surgeon (2013-10-30)
Lilly Bayouth, Karen Safcsak, Michael L Cheatham, Chadwick P Smith, Kara L Birrer, John T Promes
摘要

Pain control after traumatic rib fracture is essential to avoid respiratory complications and prolonged hospitalization. Narcotics are commonly used, but adjunctive medications such as nonsteroidal anti-inflammatory drugs may be beneficial. Twenty-one patients with traumatic rib fractures treated with both narcotics and intravenous ibuprofen (IVIb) (Treatment) were retrospectively compared with 21 age- and rib fracture-matched patients who received narcotics alone (Control). Pain medication requirements over the first 7 hospital days were evaluated. Mean daily IVIb dose was 2070 ± 880 mg. Daily intravenous morphine-equivalent requirement was 19 ± 16 vs 32 ± 24 mg (P < 0.0001). Daily narcotic requirement was significantly decreased in the Treatment group on Days 3 through 7 (P < 0.05). Total weekly narcotic requirement was significantly less among Treatment patients (P = 0.004). Highest and lowest daily pain scores were lower in the Treatment group (P < 0.05). Hospital length of stay was 4.4 ± 3.4 versus 5.4 ± 2.9 days (P = 0.32). There were no significant complications associated with IVIb therapy. Early IVIb therapy in patients with traumatic rib fractures significantly decreases narcotic requirement and results in clinically significant decreases in hospital length of stay. IVIb therapy should be initiated in patients with traumatic rib fractures to improve patient comfort and reduce narcotic requirement.

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Sigma-Aldrich
布洛芬, ≥98% (GC)
Supelco
布洛芬, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
( S )-(+)-布洛芬, ReagentPlus®, 99%
布洛芬, European Pharmacopoeia (EP) Reference Standard
Supelco
布洛芬
Supelco
布洛芬 钠盐, ≥98% (GC)
布洛芬, European Pharmacopoeia (EP) Reference Standard
Supelco
Ibuprofen 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
Sigma-Aldrich
布洛芬, meets USP testing specifications