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Cobalt derivatives as promising therapeutic agents.

Cobalt derivatives as promising therapeutic agents.

Current opinion in chemical biology (2012-12-29)

Marie C Heffern, Natsuho Yamamoto, Robert J Holbrook, Amanda L Eckermann, Thomas J Meade

摘要

Inorganic complexes are versatile platforms for the development of potent and selective pharmaceutical agents. Cobalt possesses a diverse array of properties that can be manipulated to yield promising drug candidates. Investigations into the mechanism of cobalt therapeutic agents can provide valuable insight into the physicochemical properties that can be harnessed for drug development. This review presents examples of bioactive cobalt complexes with special attention to their mechanisms of action. Specifically, cobalt complexes that elicit biological effects through protein inhibition, modification of drug activity, and bioreductive activation are discussed. Insights gained from these examples reveal features of cobalt that can be rationally tuned to produce therapeutics with high specificity and improved efficacy for the biomolecule or pathway of interest.

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Sigma-Aldrich

钴, powder, 2 μm particle size, 99.8% trace metals basis

Sigma-Aldrich

钴, granular, 99.99% trace metals basis

Sigma-Aldrich

钴, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%

Sigma-Aldrich

钴, pieces, 99.5% trace metals basis

Sigma-Aldrich

钴, wire, diam. 1.0 mm, 99.995% trace metals basis

Sigma-Aldrich

钴, foil, thickness 0.1 mm, 99.95% trace metals basis

Sigma-Aldrich

钴, foil, thickness 1.0 mm, 99.95% trace metals basis

Sigma-Aldrich

钴, foil, thickness 0.1 mm, ≥99.99%

Sigma-Aldrich

钴, rod, diam. 5.0 mm, 99.95% trace metals basis

钴, foil, light tested, 25x25mm, thickness 0.01mm, 99.9%

钴, foil, 4mm disks, thickness 0.05mm, annealed, 99.9%

钴, foil, 8mm disks, thickness 0.003mm, 99.9%

钴, foil, 6mm disks, thickness 0.01mm, 99.9%

钴, foil, 4mm disks, thickness 0.007mm, 99.9%

钴, foil, 8mm disks, thickness 0.01mm, 99.9%

钴, foil, 25x25mm, thickness 0.25mm, as rolled, 99.9%

钴, foil, light tested, 50x50mm, thickness 0.0125mm, 99.9%

钴, wire reel, 0.5m, diameter 0.05mm, hard, 99.9%

钴, foil, 25mm disks, thickness 0.125mm, annealed, 99.9%

钴, foil, 8mm disks, thickness 0.006mm, 99.9%

钴, foil, 4mm disks, thickness 0.025mm, 99.9%

钴, foil, 6mm disks, thickness 0.008mm, 99.9%

钴, foil, 8mm disks, thickness 0.125mm, as rolled, 99.99+%

钴, foil, 6mm disks, thickness 0.006mm, 99.9%

钴, foil, 6mm disks, thickness 0.25mm, as rolled, 99.9%

钴, foil, 8mm disks, thickness 0.004mm, 99.9%

钴, foil, 8mm disks, thickness 0.025mm, 99.9%

钴, foil, 8mm disks, thickness 0.25mm, as rolled, 99.9%

钴, foil, light tested, 25x25mm, thickness 0.009mm, 99.9%

钴, foil, light tested, 25x25mm, thickness 0.015mm, 99.9%