Merck
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  • Multicomponent reaction of chalcones, malononitrile and DMF leading to γ-ketoamides.

Multicomponent reaction of chalcones, malononitrile and DMF leading to γ-ketoamides.

Organic & biomolecular chemistry (2014-07-11)
Enxiang Wei, Bing Liu, Shaoxia Lin, Fushun Liang
摘要

An efficient synthesis of γ-ketoamides was developed by the one-pot multicomponent reaction of chalcones, malononitrile and DMF (as both the reactant and solvent) in the presence of NaOH (3.0 equiv.). The reaction features high atom economy, easily available starting materials, operational simplicity, and good tolerance with diverse functional groups.

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Sigma-Aldrich
丙二腈, ≥99%