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- Synthesis and structure-activity relationship of cyclopentenone oximes as novel inhibitors of the production of tumor necrosis factor-α.
Synthesis and structure-activity relationship of cyclopentenone oximes as novel inhibitors of the production of tumor necrosis factor-α.
Bioorganic & medicinal chemistry letters (2014-05-24)
Yeonjoon Kim, Yong Deog Hong, Yung Hyup Joo, Byung Young Woo, Sun-Young Kim, Hyun Ju Koh, Miyoung Park, Kyoung Hee Byoun, Song Seok Shin
PMID24852119
摘要
3-Alkyl-2-aryl-2-cyclopenten-1-one oxime derivatives (1) were studied as a novel class of inhibitors of tumor necrosis factor α (TNF-α) with regard to synthesis and in vitro SAR inhibition of TNF-α. The in vitro IC50 values of these compounds in rat and human peripheral blood mononuclear cells were at the sub-micromolar level.
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