跳转至内容
Merck
CN
  • Asymmetric total synthesis of (-)-leuconoxine via chiral phosphoric acid catalyzed desymmetrization of a prochiral diester.

Asymmetric total synthesis of (-)-leuconoxine via chiral phosphoric acid catalyzed desymmetrization of a prochiral diester.

Organic letters (2014-12-20)
Kazuhiro Higuchi, Shin Suzuki, Reeko Ueda, Norifumi Oshima, Emiko Kobayashi, Masanori Tayu, Tomomi Kawasaki
PMID25522825
摘要

The asymmetric total synthesis of (-)-leuconoxine has been achieved. The desymmetrization of a prochiral diester using a chiral phosphoric acid catalyst produced a highly enantioenriched lactam with excellent yield. The ring construction featuring an intramolecular N-acyliminium cyclization and the one-step pyrrolidone formation using Bestmann's ylide was successfully accomplished.

材料
产品编号
品牌
产品描述
695017
Sigma-Aldrich
磷酸, ACS reagent, ≥85 wt. % in H2O
438081
Sigma-Aldrich
磷酸, ACS reagent, ≥85 wt. % in H2O
345245
Sigma-Aldrich
磷酸, 85 wt. % in H2O, 99.99% trace metals basis
30417
Sigma-Aldrich
磷酸, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥85%
79622
Sigma-Aldrich
磷酸, puriss. p.a., crystallized, ≥99.0% (T)
466123
Sigma-Aldrich
磷酸, crystalline, ≥99.999% trace metals basis
04107
Sigma-Aldrich
磷酸, puriss., meets analytical specification of Ph. Eur., BP, NF, FCC, 85.0-88.0%
W290017
Sigma-Aldrich
磷酸 溶液, 85 wt. % in H2O, FCC, FG
79617
Sigma-Aldrich
磷酸, BioUltra, ≥85% (T)
452289
Sigma-Aldrich
磷酸, ≥85 wt. % in H2O, ≥99.999% trace metals basis
P5811
Sigma-Aldrich
磷酸, BioReagent, suitable for insect cell culture, 85%
612162
Sigma-Aldrich
磷酸 溶液, suitable for NMR (reference standard), 85% in D2O (99.9 atom % D), NMR tube size 4.2 mm × 8 in. , WGS-5BL Coaxial NMR tube
698822
Sigma-Aldrich
磷酸 溶液, suitable for NMR (reference standard), 85% in D2O (99.9 atom % D), NMR tube size 5 mm × 8 in.
699608
Sigma-Aldrich
磷酸 溶液, suitable for NMR (reference standard), 85% in D2O (99.9 atom % D), NMR tube size 3 mm × 8 in.