- A conservative mutant of a proteolytic fragment produced during fibril formation enhances fibrillogenesis.
A conservative mutant of a proteolytic fragment produced during fibril formation enhances fibrillogenesis.
Prion (2015-01-01)
Vladimir V Egorov, Dmitry V Lebedev, Aram A Shaldzhyan, Alexey K Sirotkin, Andrey N Gorshkov, Olga A Mirgorodskaya, Natalia A Grudinina, Andrey V Vasin, Michael M Shavlovsky
PMID25551549
摘要
The fibrillogenesis of a peptide corresponding to residues 35-51 of human α-lactalbumin (¹GYDTQAIVENNESTEYG¹⁷) can be dramatically enhanced by the addition of a tetrapeptide TDYG homologous to its C-terminus (TEYG). Generation of spontaneous hydrolytic products similar to this peptide was demonstrated by mass-spectrometry analysis of GYDTQAIVENNESTEYG peptide solution components during fibrillogenesis. Possible mechanisms and roles of short peptides in protein metabolism are discussed.