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Molecular imprinted magnetic nanoparticles for controlled delivery of mitomycin C.

Molecular imprinted magnetic nanoparticles for controlled delivery of mitomycin C.

Artificial cells, nanomedicine, and biotechnology (2013-08-14)

Deniz Türkmen, Nilay Bereli, M Emin Çorman, Huma Shaikh, Sinan Akgöl, Adil Denizli

摘要

Controlled drug delivery system is a technique which has considerable recent potential in the fields of pharmacy and medicine. Mitomycin C is commonly used drug in the treatment of superficial bladder and breast cancers. In the present study, mitomycin C-imprinted magnetic poly(hydroxyethyl methacrylate)-based nanoparticles (MIMNs) were prepared using surfactant free emulsion polymerization for controlled delivery of mitomycin C. The MIMNs were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, electron spin resonance, and elemental analysis. The average particle diameter of MIMNs was about 200 nm.

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过硫酸钾, ACS reagent, ≥99.0%

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2-羟基乙基甲基丙烯酸酯, ≥99%, contains ≤50 ppm monomethyl ether hydroquinone as inhibitor

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乙二醇二甲基丙烯酸酯, 98%, contains 90-110 ppm monomethyl ether hydroquinone as inhibitor

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过二硫酸钾, puriss. p.a., ACS reagent, ≥99.0% (RT)

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2-羟基乙基甲基丙烯酸酯, contains ≤250 ppm monomethyl ether hydroquinone as inhibitor, 97%

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氧化铁(II,III), nanopowder, 50-100 nm particle size (SEM), 97% trace metals basis

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氧化铁(II,III), powder, <5 μm, 95%

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过硫酸钾, 99.99% trace metals basis

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氧化铁(II,III), 99.99% trace metals basis

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氧化铁(II,III)，磁性纳米颗粒溶液, 10 nm avg. part. size, 5 mg/mL in toluene

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氧化铁(II,III)，磁性纳米颗粒溶液, 30 nm avg. part. size (TEM), PEG functionalized, dispersion, 1 mg/mL Fe in H₂O

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氧化铁(II,III)，磁性纳米颗粒溶液, 10 nm avg. part. size, 5 mg/mL in H₂O

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氧化铁(II,III)，磁性纳米颗粒溶液, 5 nm avg. part. size, 5 mg/mL in H₂O

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氧化铁(II,III)，磁性纳米颗粒溶液, 10 nm avg. part. size (TEM), carboxylic acid functionalized, 5 mg/mL Fe in H₂O, dispersion

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氧化铁(II,III)，磁性纳米颗粒溶液, 20 nm avg. part. size, 5 mg/mL in H₂O

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氧化铁(II,III)，磁性纳米颗粒溶液, 30 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H₂O, dispersion

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2-羟基乙基甲基丙烯酸酯

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 5 nm avg. part. size, 5 mg/mL in toluene

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 20 nm avg. part. size, 5 mg/mL in toluene

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 10 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H₂O, dispersion

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 10 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H₂O, dispersion

Sigma-Aldrich

氧化铁(II,III)，磁性纳米颗粒溶液, 5 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H₂O, dispersion