Rorgamma (Rorc) is a common integration site in type B leukemogenic virus-induced T-cell lymphomas.

Rorgamma (Rorc) is a common integration site in type B leukemogenic virus-induced T-cell lymphomas.

Journal of virology (2004-04-14)

Dana R Broussard, Mary M Lozano, Jaquelin P Dudley

摘要

The retrovirus type B leukemogenic virus (TBLV) causes T-cell lymphomas in mice. We have identified the Rorgamma locus as an integration site in 19% of TBLV-induced tumors. Overexpression of one or more Rorgamma isoforms in >77% of the tumors tested may complement apoptotic effects of c-myc overexpression.