- Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc.
Novel Insights into the PKCβ-dependent Regulation of the Oxidoreductase p66Shc.
The Journal of biological chemistry (2016-09-15)
Martina Haller, Sana Khalid, Leopold Kremser, Friedrich Fresser, Tobias Furlan, Martin Hermann, Julia Guenther, Astrid Drasche, Michael Leitges, Marco Giorgio, Gottfried Baier, Herbert Lindner, Jakob Troppmair
PMID27624939
摘要
Dysfunctional mitochondria contribute to the development of many diseases and pathological conditions through the excessive production of reactive oxygen species (ROS), and, where studied, ablation of p66Shc (p66) was beneficial. p66 translocates to the mitochondria and oxidizes cytochrome c to yield H