- Association of Pasteurella multocida toxin with vimentin.
Association of Pasteurella multocida toxin with vimentin.
Infection and immunity (2002-10-16)
Hiroaki Shime, Takahiro Ohnishi, Kaori Nagao, Kiyomasa Oka, Toshifumi Takao, Yasuhiko Horiguchi
PMID12379728
摘要
To help understand the molecular mechanisms of Pasteurella multocida toxin (PMT) action, we searched for a cellular protein interacting with PMT. The ligand overlay assay revealed a 60-kDa cellular protein that binds to a region from the 840th to 985th amino acids of the toxin. This protein was identified as vimentin by peptide mass fingerprinting. The N-terminal head domain of vimentin was further found to be responsible for the binding to the toxin.