- Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo.
Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo.
Scientific reports (2017-03-03)
Ya-Ling Yin, Mo-Li Zhu, Jia Wan, Chong Zhang, Guo-Pin Pan, Jun-Xiu Lu, Song Ping, Yuan Chen, Fan-Rong Zhao, Hai-Ya Yu, Tao Guo, Xu Jian, Li-Ying Liu, Jia-Ning Zhang, Guang-Rui Wan, Shuang-Xi Wang, Peng Li
PMID28252100
摘要
Endothelial dysfunction, which is caused by endothelial nitric oxide synthase (eNOS) uncoupling, is an initial step in atherosclerosis. This study was designed to explore whether Chinese medicine xin-mai-jia (XMJ) recouples eNOS to exert anti-atherosclerotic effects. Pretreatment of XMJ (25, 50, 100 μg/ml) for 30 minutes concentration-dependently activated eNOS, improved cell viabilities, increased NO generations, and reduced ROS productions in human umbilical vein endothelial cells incubated with H