- A new saponin from Acanthopanax koreanum with anti-inflammatory activity.
A new saponin from Acanthopanax koreanum with anti-inflammatory activity.
Archives of pharmacal research (2016-12-31)
Le Duc Dat, Nguyen Phuong Thao, Bui Thi Thuy Luyen, Bui Huu Tai, Mi Hee Woo, Zahid Manzoor, Irshad Ali, Young Sang Koh, Young Ho Kim
PMID28035554
摘要
Twelve saponins were isolated from the leaves of Acanthopanax koreanum, including one new lupane-type triterpene glycoside, named acankoreoside R (1), together with 11 known triterpenoid saponins (2-12). Their structures were elucidated by 1D and 2D nuclear magnetic resonance (NMR), mass spectroscopic data (MS). All of the fractions and isolated saponins were evaluated for anti-inflammatory activities in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) by ELISA. Among them, compounds 1-5, 7, 10, and 12 showed strong inhibitions towards interleukin-12 (IL-12) production with IC
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