Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic β-cells.

Insulin release from pancreatic β-cells is controlled by plasma glucose levels via mitochondrial fuel metabolism. Therefore, insulin secretion is critically dependent on mitochondrial DNA (mtDNA) and the genes it encodes. Mitochondrial transcription factor B2 (TFB2M) controls transcription of mitochondrial-encoded genes. However, its precise role in mitochondrial metabolism in pancreatic β-cells and, consequently, in insulin secretion remains unknown. To elucidate the role of TFB2M in mitochondrial function and insulin secretion There was an effect of gene dosage on Loss of