Designing of peptide substrates. Different approaches exemplified by new chromogenic substrates for kallikreins and urokinase.

Designing of peptide substrates. Different approaches exemplified by new chromogenic substrates for kallikreins and urokinase.

Haemostasis (1978-01-01)

G Claeson, L Aurell, P Friberger, S Gustavsson, G Karlsson

摘要

Chromogenic peptide substrates for serine proteases have been designed by using two approaches: (1) by using the natural substrate as a model and (2) by structure-activity correlations obtained through screening of a large number of tripeptides. Some recent examples, substrates for kallikreins and urokinase are given.

材料

Product Number

品牌

产品描述

B2133

Sigma-Aldrich

N-Benzoyl-Pro-Phe-Arg-p-nitroanilide hydrochloride, protease substrate