- Allospecific Memory B Cell Responses Are Dependent on Autophagy.
Allospecific Memory B Cell Responses Are Dependent on Autophagy.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2017-06-18)
M Fribourg, J Ni, F Nina Papavasiliou, Z Yue, P S Heeger, J S Leventhal
PMID28621910
摘要
Long-lived, donor-reactive memory B cells (Bmems) can produce alloantibodies that mediate transplant injury. Autophagy, an intrinsic mechanism of cell organelle/component recycling, is required for Bmem survival in infectious and model antigen systems, but whether autophagy affects alloreactive Bmem is unknown. We studied mice with an inducible yellow fluorescent protein (YFP) reporter expressed under the activation-induced cytidine deaminase (AID) promoter active in B cells undergoing germinal center reactions. Up to 12 months after allogeneic sensitization, splenic YFP
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