Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor.

Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor.

Molecular therapy. Nucleic acids (2017-12-17)

Alexander Falkenhagen, Jastaranpreet Singh, Sabah Asad, Danila Leontyev, Stanley Read, Juan Carlos Zúñiga-Pflücker, Sadhna Joshi

PMID29246292

摘要

HIV entry inhibitors are highly effective in controlling virus replication. We have developed a lentiviral vector that expresses a secreted entry inhibitor, soluble CD4 (sCD4), which binds to the HIV envelope glycoproteins and inactivates the virus. We have shown that sCD4 was secreted from gene-modified CD4