NACP-REP1 polymorphism is not involved in Parkinson's disease: a case-control study in a population sample from southern Italy.

NACP-REP1 polymorphism is not involved in Parkinson's disease: a case-control study in a population sample from southern Italy.

Neuroscience letters (2003-10-30)

P Spadafora, G Annesi, A A Pasqua, P Serra, I C Cirò Candiano, S Carrideo, P Tarantino, D Civitelli, E V De Marco, G Nicoletti, F Annesi, A Quattrone

PMID14583385

摘要

Contradictory evidence has been reported on the role of the polymorphic mixed dinucleotide repeat (NACP-REP1) of the alpha-synuclein gene as a risk factor for sporadic Parkinson's disease (PD). In the present study we genotyped the NACP-REP1 polymorphism in 189 PD patients from southern Italy and 182 healthy control subjects. We failed to demonstrate an association of any NACP-REP1 allele with PD.