Merck
CN

KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

别名:
ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1
物种:
Human KCNH2 (3757), Mouse Kcnh2 (16511), Rat Kcnh2 (117018), Zebrafish kcnh2 (405763), naked mole-rat Kcnh2 (101711977), domestic cat KCNH2 (101081621), Horse KCNH2 (100064000), Domestic Rabbit KCNH2 (100009242), dog KCNH2 (403761), domestic guinea pig Kcnh2 (100135563)
UniProtKB ID:
Q12809, A5H1P7, D3DX04, O75418, O75680, Q9BT72, Q9BUT7, Q9H3P0
基因ID:
  • Human(3757) Summary: This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
  • Mouse(16511) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Rat(117018) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Zebrafish(405763) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • naked mole-rat(101711977) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • domestic cat(101081621) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Horse(100064000) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • Domestic Rabbit(100009242) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • dog(403761) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • domestic guinea pig(100135563) potassium voltage-gated channel, subfamily H (eag-related), member 2
  • cow(539971) potassium voltage-gated channel, subfamily H (eag-related), member 2

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Small Molecule - Antagonist

货号
说明
物种
G2539
格列本脲, meets USP testing specifications,
物种
rat, human
G0639
格列本脲, ≥99% (HPLC),
物种
rat, human
L9664
氯雷他定, ≥98% (HPLC), powder,
物种
rat, human
D1414
氟哌利多, ,
物种
human
T9652
特非那定, ,
物种
mouse, rat, human

Antibodies

货号
说明
物种反应性
应用
AB5908
抗钾通道HERG抗体，CT, Chemicon®, from rabbit,
物种反应性
human
应用
immunocytochemistry
immunoprecipitation (IP)
western blot
K0640
Anti-Potassium Channel KV11.1 (HERG) Extracellular-FITC 兔抗, affinity isolated antibody, lyophilized powder,
物种反应性
human
应用
flow cytometry
immunocytochemistry
SAB2104244
Anti-KCNH2 antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
应用
western blot
AB5930
Anti-Potassium Channel ERG1 Antibody, CT, Chemicon®, from rabbit,
物种反应性
human, mouse, rat
应用
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
P0749
Anti-Potassium Channel Kv11.1 Extracellular antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
物种反应性
human
应用
flow cytometry
immunocytochemistry
western blot

Small Molecule - Blocker

货号
说明
物种
A-060
Amiodarone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®,
物种
human
I9910
Ibutilide hemifumarate salt, ≥98% (HPLC),
物种
human
1224937
多非利特, United States Pharmacopeia (USP) Reference Standard,
物种
human
1335610
Ibutilide fumarate, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 885.23 ([(C20H36N2O3S)2 . C4H4O4]),
物种
human
G2539
格列本脲, meets USP testing specifications,
物种
rat, human

Small Molecule - Inhibitor

货号
说明
物种
L9664
氯雷他定, ≥98% (HPLC), powder,
物种
rat, human
T9652
特非那定, ,
物种
mouse, rat, human
P1793
匹莫齐特, ,
物种
human, mouse, rat
H1512
氟哌啶醇, powder,
物种
human, rat
C6305
氯氮平标准液, ,
物种
human, rat

esiRNA

货号
说明
物种
EHU080951
MISSION® esiRNA, targeting human KCNH2,
物种
human