F1678
R-(−)-Fluoxetine hydrochloride
>98% (HPLC), solid
别名:
(R)-N-Methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine hydrochloride
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关于此项目
经验公式（希尔记法）:
C17H18NOF3 · HCl
化学文摘社编号:
分子量:
345.79
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
>98% (HPLC)
表单
solid
储存条件
desiccated
颜色
white
溶解性
H2O: soluble >10 mg/mL
创始人
Eli Lilly
SMILES字符串
Cl[H].CNCC[C@@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2
InChI
1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m1./s1
InChI key
GIYXAJPCNFJEHY-PKLMIRHRSA-N
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相关类别
应用
R-(−)-Fluoxetine hydrochloride has been used as a serotonin reuptake inhibitor:
- to study its effects on the embryoid body (EB) morphogenesis
- in combination with muscimol hydrobromide (MUS) as well as individually to study its neurotoxic effects on neuronal cells grown on multielectrode array (MEA) chips
- to study its effects as an endocrine disruption inducer in Pimephales promelas
生化/生理作用
Fluoxetine exhibits anti-depressant activity by increasing the serotonin levels in the neuron synaptic space. It also exhibits therapeutic effects against depression and other mood disorders.
Selective serotonin reuptake inhibitor.
特点和优势
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Erica L L Warkus et al.
Toxicological sciences : an official journal of the Society of Toxicology, 165(2), 372-388 (2018-06-13)
Fluoxetine is one of the most commonly prescribed antidepressants in the selective serotonin reuptake inhibitor (SSRI) class. Epidemiologic studies have suggested a link between maternal fluoxetine use during pregnancy and an increased incidence of birth defects. However, the mechanisms by
Bibiana Scelfo et al.
Toxicology, 299(2-3), 172-183 (2012-06-06)
Cortical neurons grown on multielectrode array (MEA) chips have been shown to be a valuable alternative method to study electrophysiological properties of the central nervous system neurons and to perform functional toxicological screening. Here we studied the effects of binary
Maria Gonzalez-Rey et al.
Environmental pollution (Barking, Essex : 1987), 173, 200-209 (2012-12-04)
Fluoxetine (FLX) the active pharmaceutical ingredient (API) in Prozac(®) is a widely prescribed psychoactive drug which ubiquitous occurrence in the aquatic environment is associated to a poor removal rate in waste-water treatment plant (WWTP) systems. This API acts as a
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Chromatograms
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